1
general::
Phrase(s): What’s with someone or something?
Why is someone or something in that condition?; What’s going on with someone or something? • Mary: What’s with Tom? He looks depressed. Bill: He broke up with Sally. • "What’s with this stupid coffee maker? It won’t get hot!" groused Alice.
McGrawhill's American Idioms And Phrasal Verbs
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Also, what's up with;what gives with. What is going on with; tell me about or explain it. For example, What's with all the food they're giving away? or What's up with Lee these days? or What gives with Jack? Why is he so glum? This idiom is Also sometimes used as a substitute for how are you or what's wrong, as in Hi, Pam, what's with you? or What gives with you? why are you yelling? [Colloquial; c. 1940]
American Heritage Idioms